The
Broad Institute, based in Cambridge, Mass., has entered an arms race with Ebola
– sequencing viral genomes from infected patient blood samples in a mere 40
hours. To stop this virus in its tracks, we need to understand disease
epidemiology in real time. Broad has
its own genome-sequencing powerhouse just down the street, with lab technicians
staffed around the clock. They laboriously prepare samples for analysis; then
50 machines churn out genome sequence data – 24 hours a day, every day of the
year. The Institute has an impressive resume, participating in the 1000 Genomes
Project and sequencing genomes of Dengue virus, West Nile virus, and
malaria-causing parasites. Now, they’ve turned their attention to Ebola and are
fast-tracking the sequencing process, which is cheaper and quicker than ever
before.
Pardis
Sabeti leads the Ebola and Lassa group at the Broad Institute, which seeks to
use genetic analysis for future diagnostic, vaccination, and treatment
development. They want to understand how the virus mutates and evades our
immune system. And conversely, how some people may have protective genetic
mutations that render them more resistant to infection. Some of their early
Ebola investigations have brought to light invaluable data regarding viral
transmission. Blood samples from infected Sierra Leone patients were swiftly
shipped to Cambridge, where Pardis’ team found interhost and intrahost
variation among the ebola virus genomes. This variation allowed the team to
clarify patterns of viral transmission and mutation in the early weeks of the
epidemic. With this, they were able to trace the origin of the Sierra Leone
outbreak to a single May 2014 funeral.
With
a disease as threatening and rapidly escalating as Ebola, the fight to end it –
let alone to just begin to control it – will take a whole army, from health
workers on the ground to white coats in a distant Cambridge lab.
Source: http://www.nytimes.com/2014/12/02/science/factory-direct-virus-analysis.html?hp&action=click&pgtype=Homepage&module=photo-spot-region®ion=top-news&WT.nav=top-news&_r=0
And more at: http://www.sciencemag.org/content/345/6202/1369
Source: http://www.nytimes.com/2014/12/02/science/factory-direct-virus-analysis.html?hp&action=click&pgtype=Homepage&module=photo-spot-region®ion=top-news&WT.nav=top-news&_r=0
And more at: http://www.sciencemag.org/content/345/6202/1369
- Emma Rastatter
6 comments:
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