How relevant! This past problem set in Humans and Viruses
asked us to discuss molecular viroarcheology – the very tool used to piece
together a previously unknown virus. As was the case in Johan Hultin’s
seroarchelogy success, freezing conditions allowed for the isolation of the
viral sample in the recently published study, “Preservation of viral genomes in
700-year-old caribou feces from a subarctic ice patch.” These conditions can preserve
the encapsidated nucleic acids for up to several centuries. A complete DNA
viral genome and a partial RNA viral genome was identified in 700-year-old caribou
feces buried beneath the ice, and reverse genetic methods allowed for
sequencing and recreation of the viral DNA genome. The suspect DNA virus is
found to resemble geminiviruses, which infect plants, and thus, the virus
likely entered the caribou’s system at some point in its herbivore diet. The team’s
proposed future direction for this data is to feed molecular genetics the viral
genome in order to regenerate the live virus and study its biology. It’s an
incredibly cool next step in science, but could it be dangerous? Should we
bring a virus out of extinction if we know little about its pathogenicity,
route of transmission, or host range? That’s food for thought.
- Emma Rastatter
4 comments:
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