Saturday, December 13, 2014

Herpes virus Replication

4)
Recently it was discovered that Herpes virus rearranges its telomeres to improve replication strategies. Telomeres are noncoding sequences that allow for the replication of DNA past the tip problem. With every subsequent iteration, a few nucleotides are lost. Therefore telomeres play an integral role in determining coil lifespan. What the study showed is that HSV-1 is able to induce the telomere repeat containing RNA (TERRA). The virus then degrades a telomere protein called TPP1 that inhibits its viral replication. This is the first instance of telomere altering as seen by viruses in an attempt to improve replication.


- Alex

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