Wednesday, December 10, 2014

Using Viruses to Help Cure Parkinson's Disease

The use of optogenetics in Parkinson's Disease research could potentially do wonders towards finding treatment and cures for the disease. Kravitz and his team published a paper in Nature that showed that optogenetics could improve an animal model of Parkinsonism! (Granted, they also showed they could worsen it). Optogenetics, which utilizes different expressed proteins to inhibit or increase neuronal firing with light, is a very useful tool in this field. 

Optogenetics use simple viral carrier systems that help deliver genes to the neurons; opsins (Channel rhodopsin being used to activate firing potentials and Halorhodopsin to inhibit them with different wavelengths of light) allow for this to happen, and ultimately allow for neuronal firing to be manipulated at precise milisecond intervals. 


In the case of the Parkinsonian research, the experiment performed was a manipulation of the basal ganglial pathways (which are suspects implied in PD). There was optogenetic control via channelrhodospin of MSNs (medium spiny projection neurons) as well as regulation of dopamine receptors. If the direct pathway was activated, there was an increase of locomotion as well as a reduction of "freezing", which had been observed when the indirect pathway was activated and parkinsonian states were elicited (which had decreased locomotion and increased freezing). Intrigued to see where this will go in the future!

-Meche

Read more: http://www.nature.com/nature/journal/v466/n7306/abs/nature09159.html

2 comments:

Unknown said...

I was diagnosed of Parkinson's disease following a neurological examination and other series of tests, my symptoms first appeared in February 2014 tremor in both limbs, rigid muscle, impaired posture.. all medication prescribed were not working and i sadly took off from my job, being a single mother with two kids it was almost a hopeless situation. In September 2016, i read about Dr Abumere herbal center in a health forum, this herbal center have successful parkinson's disease herbal treatment and treatment for other list of terminal diseases, i contacted the herbal center via their email and purchased the parkinson's disease herbal remedy. I received the parkinson's disease herbal remedy via courier and immediately commenced usage. I used the remedy for 14 days, all my symptoms including tremor gradually disappeared till i almost forgot i had the disease, i have started working again, thanks to Dr Abumere herbal center. abumereherbalcentre@gmail.com Parkinson's disease is not a death sentence, don't die believing there is no cure, its a final breakthrough for all living with parkinson's disease.

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