An innovative approach that
utilizes the differential expression profiles of certain proteins expressed by
tumor cells and healthy cells that functions to promote preference for tropism
in tumor cells. Scientists at the IDIBAPS
Biomedical Research Institute and at the Institute for Research in Biomedicine
(IRB Barcelona) lead a study in which they have designed a new strategy to get
genetically modified viruses to selectively attack tumor cells without affecting
healthy tissues. Researchers used adenovirus as the viral vector and manipulated
the expression of the specific type host cell protein, CPEBs, to allow for this
differentiation in tropism. CPEB is a family of four RNA binding proteins, the
molecules that carry information from genes to synthesize proteins, that
control the expression of hundreds of genes and maintain the functionality and
the ability to repair tissues under normal conditions. When CPEBs become
imbalanced, they change the expression of these genes in cells and contribute
to the development of pathological processes such as cancer. The vector was
then manipulated to favorably recognize CPEB proteins and their states of CPEB1
and CPEB4, which upon simplification, allows the virus to selectively determine
which cells are tumorigenic and favorably infect them. This type of research
has been in development for a long while now with few breakthrough, however,
continued research is providing more hope into the treatment of cancers with non-other
than a major pathogenic agent.
-Ethan Wentworth
1 comment:
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