A
new manipulation of the vaccinia genome has been found to be an effective
treatment of certain cancers. More
specifically, researchers have deleted the F4L gene, which codes for the enzyme
ribonucleotide reductase, and have now been able to produce a selective
oncolytic-virus promoting anti-tumor immunity in bladder cancers. Regarding cancer therapies, viral vectors are
among some of the safest due to the low prevalence of side effects or secondary
interactions when compared to something like chemotherapy which lacks the
precision in cell killing or surgery which lacks the broad-spectrum
applicability. Further studies with this
manipulated virus strongly support the original correlational claim when
observing successful results in both ex vivo cultures and mouse models. A virus of historical significance is still
influencing the treatment of deadly diseases in the modern era, but will it
have as great an impact as it did in the past?
-Ethan Wentworth
1 comment:
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