Saturday, March 18, 2017

Early Antibody Treatment in SIV enables virus control

Researchers at Rockefeller University in New York and the National Institutes of Health has shown early antibody treatment as a means to allow for durable control of HIV-like SIV viruses in macaque monkeys. 13 such monkeys were inoculated with the virus, and then given three infusion of two antibodies over a two-week period. Once antibodies cleared out, viral titers first rebounded, but then declined significantly, remaining undetectable for 5 to 13 months. 10 of 13 monkeys were observed to  have objectively benefited from the antibody therapy.

To determine the feasibility of such a therapy in humans, researchers intend to carry out a version of the study involving antibody administration at a point much later in the course of infection, in order to better mimic the delayed time until HIV is detected in human cases.


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