In Portland State University, researchers have been studying
a virus that infects single celled organisms. The virus, called archaeal
fusellovirus SSV1, is found in extreme conditions near boiling and acidic hot springs
with volcanic activity. It is one of the better-characterized Achaea infecting viruses,
which are notoriously so diverse that it’s difficult to surmise what their
genes could possibly be used for.
In their study, the researchers selectively removed certain
genes from the virus to see if it could still infect its host. Amazingly, they
were able to disrupt about half of the genes and the virus was still able to
replicate. This included one of the minor glycoproteins vp3. Although capsid
morphology was abnormal post modification, it was still functional.
The researchers state that this will help us understand
viral mutation, in particular with viruses like HIV. I’m a little skeptical given
the fact that they don’t necessarily share a single gene in common, but
perhaps, like the central dogma, understanding one component is transferable to
another component
Elisa Hofmeister ‘18
Press release:
Manuscript:
http://jvi.asm.org/content/early/2017/01/26/JVI.02406-16.full.pdf
1 comment:
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