An article in the March 2015 issue of Cell, "Hepatitis C Virus RNA Functionally Sequesters miR-122," by Luna et al. establishes this phenomenon. The researchers, who conducted their work at Rockefeller University, posit that their conclusions suggest strongly that miRNA-122 should be a target molecule in drug development.
microRNA is an RNA subtype specifically equipped to dampen gene expression by recruiting "silencing proteins" to an mRNA transcript before it can be translated. miRNA-122 in particular governs the gene expression of factors involved in crucial functions like iron and cholesterol metabolism and circadian rhythms.
--Shubha Raghvendra
Source: Luna, J M et al. "Hepatitis C Virus RNA Functionally Sequesters miR-122." Cell. 2015: vol. 160, no. 6. http://www.sciencedirect.com/science/article/pii/S0092867415001919.
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