Alisertib is now being used to treat HPV induced cancers in mice with incredible efficacy. Researchers from Griffith University, located in Gold Coast, Australia, have successfully cured cancers of the cervix, head, neck, and skin in mice caused by Human Papilloma Virus.
The drug is a a small-molecule inhibitor of the Aurora A Kinase (AAK), an enzyme that is over expressed in several types of tumors and has been associated with oncogenesis. According Crane et al., the Aurora family of kinases is integral in ensuring successful cell division, and is involved in Mitotic progression and checkpoint control pathways in the cell.
Although there are already effective vaccines against cervical cancers caused by HPV, Nigel McMillan and Brian Gabrielli think this drug may be the next step towards reducing the overall mortality rates. Due to the specificity of the drug and the use of Alisertib to treat other cancers in humans already, McMillan and Gabrielli believe they have found a more appropriate and new use for compound developed by The Takeda Oncology Company.
The treatments available to those diagnosed with cervical cancer are radiation, chemotherapy, or a full hysterectomy. This drug may provide women with a more effective and desirable treatment.
- Marcus Munoz