While most viruses have a very dense conglomeration of structural proteins on the virion surface, essentially helping increase the integrity of the structure, HIV has a low amount of protein spikes on its envelope. This paper argues that by evolving a low density of these envelope protein spikes, there is prevention of immunoglobulin G antibodies binding to the virion, which in turn slows down the antibody response as well as the neutralizing antibody response. The latter has been known to be very slow to develop in case of HIV infection, and the low density of envelope proteins is thought to be the answer to this conundrum.
This information is particularly relevant when thinking about vaccine development for HIV, as this paper suggests using this knowledge to create a "virus-like display" vaccine that would generate neutralizing antibodies and as a result, an HIV prophylactic vaccine . I invite you to read more on the specifics at http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1004254
Virophilically truly,
Meche Peterson
Subscribe to:
Post Comments (Atom)
1 comment:
5 years ago I had warts, I was treated with some liquid applied to the warts they continued to grow and spread... The next 2 doctors did laser surgery to remove them. 1 year after the surgery, they grew back close to where the 1st ones were' so I was finally told it was hpv. I have had it for very long time, I contract it from my cheated boyfriend and I found out he was also infected and I end up the relationship between us. the warts was so embarrasses because it started spreading all over I have be dealing with this things for very long time the last treatment I take was About 2 years ago I applied natural treatment from Dr onokun herbal cure, a week after applying the treatment all the warts was gone. it's now 2 years and some months I don't have single wart or any symptoms of hpv. wow"" it's great, Dr onokun has finally cured me. Anyone living with hpv contact Dr onokun for natural treatment.
His email address: dronokunherbalcure@gmail.com
Post a Comment