It has been known since last year that Covid-19 could cause problematic "long haul" symptoms such as brain fog and other cognitive difficulties. Recent research has shed a light on why these could be occurring-- SARS-CoV-2 is entering the brain, which is quite frightening.
A recent study published in Nature Neuroscience looked at the spike protein called S1 in SARS-CoV-2 can cross the blood brain barrier in mice. The spike protein in itself can detach by itself and lead to a cytokine storm in the brain. The virus entering into the brain could be even more detrimental since the spike protein can cause these concerning effects on its own. The spike protein attaching to blood brain barrier receptors can cause the brain to release inflammatory products such as cytokines. The overreactive immune system is a common occurrence with COVID-19; this type of overreaction in the brain could cause inflammation and issues in such an important organ in our body.
An interesting finding for William A Banks, a professor of medicine at the University of Washington School of Medicine, is how similar the S1 protein in SARS-CoV2 is to the gp120 protein in HIV. Both proteins are termed glycoproteins for their high presence of sugars, and both also have similar functions in terms of getting into the brain.
COVID-19 has already demonstrated a plethora of concerning long-term symptoms and syndromes. If people weren't concerned before, this finding of the virus' ability to penetrate into the brain could indicate complications which outlast the 10 day course of the disease common for many people.
-Sammy
https://www.sciencedaily.com/releases/2020/12/201217154046.htm
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