About 30 to 60 percent of patients continue to
experience arthritis and joint pain for months to years following the acute
infection time (with fevers, chills and acute infection). Recently, these symptoms
have gained a better physiologic foundation. It seems that myofibers and dermal
and muscle fibroblasts show signs of persistent infection in mice models. At
this point, it has been shown that cells can survive CHIKV infection. It has
been difficult to understand where persistent CHIKV RNA resides in the human
body, but the recent findings of persistent RNA (which is thought to contribute
to chronic arthritis) imply that the reporter virus system used may be useful
for further understanding mechanisms of chronic pathogenesis.
-Micah
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