A trial among members of the U.S. Army showed that the modified vaccinia Anarka (MVA) vaccine is non-inferior to the currently stockpiled ACAM2000.
The current ACAM2000 smallpox vaccine is licensed and stockpiled by the U.S., but causes skin lesions that, while less severe than previous vaccines, can be serious in immunocompromised individuals. Since the new MVA vaccine does not replicate in cells, there were no cutaneous reactions seen with the vaccine.
There were two groups in this study: one received the MVA vaccine at weeks 0 and 4 and then the ACAM2000 at week 8, while the control group received only the ACAM2000 vaccine at week 0. The day 14 mean titre was identical between the two groups at 16.2, and percentages of seroconversion were similar, with 90.8% in the MVA group and 91.8 in the ACAM2000. The MVA group also exhibited a median of 0 square milllimeters of major cutaneous reactions, while the ACAM2000 group showed a median of 76 square milllimeters. There was also a significantly lower amount of adverse events reported in the MVA group.
Since the immune titers were not assessed long term before the subjects were given the ACAM2000 vaccine, follow up study should be necessary to ensure that the MVA induces long-lasting immunity on its own.
Jacob Thoenen
Sources:
1. Vaccine Effective Against Smallpox in Military: Pivotal Trial
2. Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox
The current ACAM2000 smallpox vaccine is licensed and stockpiled by the U.S., but causes skin lesions that, while less severe than previous vaccines, can be serious in immunocompromised individuals. Since the new MVA vaccine does not replicate in cells, there were no cutaneous reactions seen with the vaccine.
There were two groups in this study: one received the MVA vaccine at weeks 0 and 4 and then the ACAM2000 at week 8, while the control group received only the ACAM2000 vaccine at week 0. The day 14 mean titre was identical between the two groups at 16.2, and percentages of seroconversion were similar, with 90.8% in the MVA group and 91.8 in the ACAM2000. The MVA group also exhibited a median of 0 square milllimeters of major cutaneous reactions, while the ACAM2000 group showed a median of 76 square milllimeters. There was also a significantly lower amount of adverse events reported in the MVA group.
Since the immune titers were not assessed long term before the subjects were given the ACAM2000 vaccine, follow up study should be necessary to ensure that the MVA induces long-lasting immunity on its own.
Jacob Thoenen
Sources:
1. Vaccine Effective Against Smallpox in Military: Pivotal Trial
2. Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox
5 comments:
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