Tuesday, February 4, 2020

A New Class of Antivirals? Using Sugar-Based Drugs

While antiviral treatments against some viruses such as HIV have progressed significantly over the past couple of decades, for other bugs, our approach remains relatively crude and toxic to the body, which leads to a whole host of side effects. Furthermore, most current drugs prevent viral replication and growth, but viruses can evolve and mutate to become resistant. An international team of researchers designed “modified cyclodextrin” sugar drugs that attract the viruses, disrupt the capsid proteins and eliminate the virus essentially on contact. There are two additional benefits of this approach: 1) It is not toxic to the host, thereby limiting dangers and side effects; and 2) It is theoretically resistant to drug resistance! The researchers successfully tested the antivirals extensively on HSV-2 and also on RSV. With continued proof on concepts, the drug could be adapted to fight other viruses such as HSV-1, hepatitis C, HIV, and Zika. 
~Avi Kaye

Article: Jones et al. Modified cyclodextrins as broad-spectrum antivirals. Science Advances, 2020; 6(5). DOI: 10.1126/sciadv.aax9318

6 comments:

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