Saturday, February 8, 2020

Big Data Payoff in 2019-nCoV Virus Illustrates the Value of Knowledge

What value do we put on knowledge? It is a core topic of epistemology. A few weeks ago, I wrote about the Global Virome Project (GVP) and its mission to map the genomes of the viruses in the animal kingdom. I also mentioned critics of the project believe money should be spent on fighting infectious disease outbreaks, not on identifying non-human viruses that may or may not ever cause an outbreak (4). In other words, the skeptics do not see any human or scientific value in the GVP vision—a virus database.

These critics may reconsider and re-evaluate their position in light of the current coronavirus outbreak in China. The probable natural reservoir of the culprit coronavirus, bat, was quickly identified due to works by virologist Dr. Shi Zhengli 石正麗 and her team. Dr. Shi has set herself and her team the task of mapping all the viruses bats carry (1). Dr. Shi was one of the scientists who identified that bats are the natural hosts for Sars. She is also the builder of the world’s largest database on bat-related viruses. For the past eight years, she and her team have been “caving” for bats in China. They have “caved” in 28 Chinese provinces and collected samples from over 10,000 bats and 2,000 other species (3). When her team ran the genome of the new coronavirus against their database, they found a 96% match in a ragt13 coronavirus found in a fruit bat in the Yunnan province (5). If her database hadn’t existed, the path to knowledge of the current coronavirus outbreak would have taken much longer.

~~ You Jia Zhu

1. Stephen Chen, “Coronavirus: bat scientist’s cave exploits offer hope to beat virus ‘sneakier than Sars’, South China Morning Post, Feb. 6, 2020.

2. Guojie Zhang, Christopher Cowled, Zhengli Shi, et al, “Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity”, Science 339, No. 6118: 456-460.

3. Jon Cohen, “Mining coronavirus genomes for clues to the outbreak’s origins”, Science, Jan. 13, 2020.

4. Olga Jonas and Richard Seifman, “Do we need a Global Virome Project?”, The Lancet Global Health, vol. 7, issue 10, October 2019, pp. 314-6.

5. 杨睿, 冯禹丁, 赵今朝, “石正丽回应质疑 专家一致认为新冠病毒非人造”, 《财新》2020年2月5日。Yang Rui, Feng Yu-ding, Zhao Jinzhao, “Shi Zhengli Responds to Questions, Experts Agree the New Coronavirus Are Not Created in a Lab”, Caixin, Feb. 5, 2020.

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