PRO-Med story on recommendations to vaccinate inmates for influenza based on the belief that MRSA may be a complicating factor in the severity of illness from influenza infection. MRSA has become a common infection among IV drug users, who the author believes, composes a fair proportion of the prison population in California. MRSA is the main cause of soft tissue infections and of severe infections like endocarditits and bacetemia. An epidemic of MRSA has been spreading in Europe and Nroth America where IV drug users have a higher colonization rate of MRSA than the general population. Why this association has been observed is unknown.