Hey guys! I just found a paper recently published in the Journal of Virology by Jolly et al showing that integrin-ICAM interactions have an important function in cell-cell spread of HIV-1 by contributing to virological synapse (VS) formation and function. In the absence of this integrin leukocyte function associated antigen, HIV-1 spread from cell to cell is significantly impaired. This suggests that adhesion molecules are required for HIV-1 dissemination in infected hosts--information that could potentially be used in the development of new HIV antiviral therapeutics.
-Ani
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