Saturday, March 7, 2020

Obesity promotes change in Influenza Virus

Researchers have noted that obesity may act as a risk factor for increased severity of influenza A infection, high levels of viral titers, and prolonged length of viral shedding. Thus, it is important to understand whether a factor such as obesity might also impact the diversity of the Influenza virus.

Using genetically obese mice to conduct experimental models, researchers studied the effects of the obese microenvironment on the evolution of the virus in vivo. Next-generation sequencing showed that obese host-passaged viruses was correlated with higher mortality in the following WT host. This implies that viral (instead of host) determine virulence. Human primary respiratory epithelial cells were studied, and increased viral replication along with blunted interferon response occurred in obese donors. 

-Micah


Sources:

12 comments:

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