Today, Baturcam et al.’s article “Human Metapneumovirus
Impairs Apoptosis of Nasal Epithelial Cells in Asthma via HSP70” was published
online. A major motivation of this study came from the fact that people with
asthma are vulnerable to viral respiratory infections, but not much is known
about the precise mechanisms for different viruses. So, the research team
generated a study to investigate the differences in immune response of adult asthmatics
vs non-asthmatics when their nasal epithelial cells were exposed to either
human metapneumovirus or respiratory syncytial virus in cell culture.
The results showed that nasal epithelial cells of asthmatics
were infected with human metapneumovirus 2.5-fold more than non-asthmatic nasal
epithelial cells (p < 0.05). There was no difference for RSV infection.
Additionally, asthma-status was linked to impaired apoptosis in nasal
epithelial cells infected with human metapneumovirus (p <0 .0001="" a="" an="" apoptosis="" but="" defect="" due="" expression="" host="" however="" hsp70="" human="" in="" inhibitor.="" interaction="" lead="" mechanism="" metapneumovirus="" not="" o:p="" of="" protein="" rather="" specific="" that="" the="" this="" to="" was="" with="">
Future research directions include targeting HSP70 as an
antiviral human metapneumovirus, which would, in turn, act as a therapeutic
asthma intervention strategy.
Read more here: http://www.karger.com/Article/FullText/449101
~Jazzmin Williams
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