Tuesday, November 1, 2016

Recent dengue vaccine associated with exacerbated zika outbreak

Tang, Xiao, Wu recently published their work on a mathematical model that predicts how dengue vaccination can exacerbate the incidence of zika during peak outbreak. It is well known that zika and dengue are both flavirviruses transmitted by mosquitos and are present in tropical and subtropical regions of the world.

Recent studies have shown that antibodies to dengue can actually facilitate zika infection. Dengue and zika co-infection has been documented in a handful of cases in South America, and there is reason to suspect that co-infection may be on the rise.

The model predicted that vaccination against dengue is associated with heightened zika infection, a greater number of people infected at the peak of the outbreak, and an earlier peak of outbreak when there are 10,000 or more infected mosquitos. Fortunately, the model emphasized decreased risk of these outcomes with shorter mosquito lifespans.

The researchers concluded that more research is warranted exploring the relationship between dengue and zika co-infection and also between dengue vaccine and zika infection. Additionally, the researchers suggest continuing mosquito control measures in the interim.

Read more here: http://www.nature.com/articles/srep35623


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