DNA Mismatch Repair Proteins are a highly conserved group of proteins from prokaryotes to higher eukaryotes and perform a number of important functions to maintain the integrity of the genome within an organism. Mutations in these genes can cause several forms of early-onset cancer. They also play an undefined role in signaling cell cycle checkpoints as well as apoptosis. Kareem Mohni and other scientists studied these cells in Herpes Simplex Virus-cell interactions to shed some light on the methods of HSV DNA replication. Specifically, they looked at MSH1 and MSH2, which usually function together in an MSH2-dependent manner.
This paper shows a novel pathway in that , in HSV replication, MSH1 does not act in an MSH2-dependent manner. Depletion of MSH1 exerted a very strong effect viral infection - specifically on immediate-early viral gene expression. MSh1 also localizes to ND10 nuclear bodies, which in turn are recuited viral replication compartments following infection. MSH2 however, is not localized to the ND10 bodies and had a later effect on gene replication.
Check out the article here.
-Emily Pollock
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