Researchers learned the value of mRNA during COVID vaccines, now they are trying to apply this to HIV.
Recently, associate professor Emmanuel Ho has developed a novel nanomedicine based on siRNA in gene therapy. Normally, HIV produces a protein called Nef which prevents autophagy, the process by which the body gets rid of pathogens. In addition, the gene CCR5 in HIV assists viral entry into cells.
The new gene therapy, a ph-sensitive dual preventative siRNA-based nanomicrobicide targets both the Nef and CCR5 gene and prevents infection in vaginal CD4+ cells. The therapy is composed of siRNA-PEI encapsulated PLGA-PEG nanoparticles and knocks down both genes. The siRNAs are mainly released in neutral pH conditions.
No comments:
Post a Comment