Avian flu use a reproductive aid protein called ANP32 protein, which causes the virus to jump from birds to mammals. These proteins are found to be tucked into viral particles and help recruit proteins to form polymerases in mammalian cells.
In mammalian cells, researchers have found that some bird ANP32 proteins are attached to the virus; researchers suspect that the viral particles is attached to the polymerase and gets bundled into the viral particle along with the rest of the machinery
However, a question remains regarding the mechanisms that the virus uses to invade mammalian cells. Two likely hypotheses for the mechanisms include: 1. Mutations caused the virus to be able to mobilize human/mammalian ANP32; 2. Avian ANP32 are tucked into viral particles that aid reproduction in mammals.
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