Opioid abuse and overdose are one of the major public health threats of our time. A study by Butt et al. shows that a higher risk of prescription opioid use might be higher among chronic hepatitis C patients due to higher comorbidity burden and social vulnerability. All individuals with a confirmed chronic Hepatitis C infection from the Electronically Retrieved Cohort of HCV Infected Veterans data set were included in this study. Butt et al. measured acute and long-term prescription opioid use defined as having a drug supply of 90 days or more. Statistical analyses included chi-square and t-tests to determine the proportion of individuals with acute and chronic long term prescription opioid use by various social factors such as race, gender, homelessness, poverty (annual income <$45,200), rural/non-rural residence, alcohol use and diagnosis of psychiatric illness. Logistic regression analyses were also included to determine the risks of factors associated with the outcome of interest. The results show that among 160,856 chronic hepatitis C cases, 38.4% had acute prescription opioid use. This was significant with a p-value of 0.01. Additionally, those with chronic Hepatitis C were 60% more likely to develop chronic long term prescription opioid use (95%CI 1.63, 1.69). Black females who experienced homelessness were at the highest risk for developing chronic long term POU. Individuals with chronic hepatitis C had, in general, more social vulnerability factors compared to control groups.
Although Butt et al. the long term effects of prescription use of opioids do require further study, this study adds to the pile of evidence that calls for addressing the public health threat that is opioid drug overdose and abuse.
-Bethel
https://www.nature.com/articles/s41598-021-85283-6
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