At the Georgia Institute of Technology, researchers have developed a new treatment utilizing CRISPR to target RNA molecules. The treatment would theoretically be given to humans via a nebulizer, which would be a relatively easy way to distribute the treatment once in the hands of patients.
The researchers had the mRNA technology code for a protein, Cas13a, that destroys parts of code that viruses use to replicate in the lungs. They were able to devise the treatment for flu and COVID-19 because the only change required was the guide strand—which is what tells the Cas13a protein where to attach to the RNA and destroy it. For the flu, the protein goes for the polymerase genes in replication. The treatment also is able to attack SARS-CoV-2 at conserved targets even given the variants circulating. As we know, influenza and SARS-CoV-2 have incredibly different genomes; this subtle change based upon each viruses’ genetic code is an amazing opportunity for multi-purpose treatment for respiratory viruses.
The research trials showed that the protein can work for 99% of flu strains circulating, and also produced no side effects in animal models and helped them to fully recover. More work must be done on the safety of these treatments before human trials can begin; however, the mRNA does not get into your nucleus and affect the DNA and is relatively transient in the body as well. After successful vaccines so far, the data on successful treatments is very encouraging to see. - Sammy
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