New research from the Baker Institute provides a more in depth look at how the herpes virus alternates between dormant and active stages of infection. The virus, which infects almost all individuals, can cause symptoms both mild, like cold sores, to severe, like encephalitis and corneal blindness in newborns. Dr. Luis M. Schang and his group found that the virus switches from its latent to lytic stage depending on how tightly its DNA is packaged into chromatin. When the herpes virus enters a host cell, the cell tries to protect itself by wrapping the viral DNA tightly around histones and condensing it into chromatin, causing the virus to go dormant. However, if the cells are unsuccessful, the chromatin is only loosely bundled, leaving some of the viral DNA accessible. The virions can then turn on their genes and replicate using cellular machinery to go into their lytic phase. With this new knowledge, researchers hope to further explore the interplay between the virus and the host cells that determine whether viral DNA is expressed. These finds open up new directions for exploring vaccines and antivirals.
- Miao G.
4 comments:
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