A recent study in the Emerging
Infectious Disease Journal, led by Julu Bhatnagar, has provided some new
information regarding replication of Zika virus in infected mothers, and in their
infants. Studying 52 cases – 44 women suspected of getting infected with Zika
virus during pregnancy, and 8 infants with microcephaly who later died, the
group found that Zika virus continues replicating in infant neurons and degenerating
glial cells after birth, via in situ hybridization assay. This reaffirms work from previous
in vitro and mice studies, which suggested that the virus infects neural
progenitor cells. The team also found that Zika virus mRNA levels were over 1,000
times greater in infant brain tissues than in placentas, where they also continue to persist, through use of real
time quantitative reverse transcription PCR.
These findings have strengthened the virus’ link to microcephaly,
and demonstrated its longevity in both infected mothers and newborn infants.
In addition, it supports the notion of the viral infection being extremely
detrimental during the first trimester of pregnancy, as 12 of 14 women who had spontaneous abortions, appeared to contract the virus then.
Ahmed Mustafa (’18)
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