A new antiviral drug is being developed which could protect against smallpox and other related viruses. Bonus is that it has already performed well in the first test of its safety and activity in humans. It's called ST-246, and was recently tested in 38 volunteers. At the moment, the only "treatment" for smallpox is vaccination within 4 days of exposure. As we learned, cidofovir has also been used. So in case smallpox is leaked again, we might have something to rely on.
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Full story at http://www.cidrap.umn.edu/cidrap/content/bt/smallpox/news/may0808poxdrug.html